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And in MBZ-OS group, the time reaching to the plasma peaks was somewhat delayed compared to MBZ-1 tragacanth group. As seen in Figure 1, the concentration-time profiles of cyst fluid and cyst wall were almost same. Thereafter, the drug levels declined but still higher than MBZ-1 tragacanth till the end of the experiment period.
During the 24 h post-administration, the drug concentrations of MBZ-OS were higher than that of MBZ-1 tragacanth in spleen and kidney, with a delayed time reaching the drug peak concentration (Figure 1 ). But for parasite and tissues, the mean T max values were numerically different between two treated groups.